Trials / Completed
CompletedNCT01625143
Studying Genes in Samples From Younger Patients With Relapsed Acute Lymphoblastic Leukemia
Molecular Taxonomy of Pediatric Cancer
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 40 (estimated)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- 21 Years
- Healthy volunteers
- Not accepted
Summary
This laboratory study is looking into genes in samples from younger patients with relapsed acute lymphoblastic leukemia. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
Detailed description
OBJECTIVES: I. To identify global changes in the epigenome and various underlying histone modifications that characterize relapsed acute lymphoblastic leukemia (ALL). II. To identify specific transcription factor-binding sites associated with histone alterations. III. To correlate gene expression changes of differentially regulated genes at relapse with underlying chromatin modifications. OUTLINE: Archived bone marrow samples, collected at the time of diagnosis and relapse, are analyzed for gene expression and histone modifications by microarray, chromatin immunoprecipitation (ChIP) sequencing, and quantitative real-time polymerase chain reaction (qRT-PCR).
Conditions
- B-cell Childhood Acute Lymphoblastic Leukemia
- Recurrent Childhood Acute Lymphoblastic Leukemia
- Untreated Childhood Acute Lymphoblastic Leukemia
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | laboratory biomarker analysis | Correlative studies |
Timeline
- Start date
- 2012-06-01
- Primary completion
- 2016-05-01
- First posted
- 2012-06-21
- Last updated
- 2016-05-18
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT01625143. Inclusion in this directory is not an endorsement.