NCT01623856

Studying Genes Associated With Non-Hodgkin Lymphoma in Young Patients

Observational - Candidate Gene Variants and Childhood/Adolescent Non-Hodgkin Lymphoma: A Preliminary Investigation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 483 (actual)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: 20 Years
• Healthy volunteers: Accepted

Summary

This research studies genes associated with non-Hodgkin lymphoma in young patients. Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer

Detailed description

OBJECTIVES: I. To conduct a preliminary investigation of the effects of loci strongly and consistently associated in prior genome-wide association studies (GWAS) and validation studies of childhood/adolescent acute lymphoblastic leukemia (ALL), adult non-Hodgkin lymphoma (NHL), autoimmune diseases, and atopic diseases on the risk of NHL (lymphoblastic and Burkitt lymphomas) in children and adolescents. OUTLINE: DNA samples are analyzed by single nucleotide polymorphism and genotyped by fluorogenic polymerase chain reaction (PCR)-based allelic discrimination (Taqman) assays using the ABI Prism 7900HT reverse transcriptase (RT)-PCR system.

Conditions

• Childhood Burkitt Lymphoma
• Childhood Lymphoblastic Lymphoma

Interventions

Type	Name	Description
OTHER	laboratory biomarker analysis	Correlative studies

Timeline

• Start date: 2012-06-01
• Primary completion: 2012-06-01
• Completion: 2012-06-01
• First posted: 2012-06-20
• Last updated: 2015-05-07

Locations

1 site across 1 country: United States