NCT01623752

Prospective Evaluation of the Radiographic Efficacy of Enbrel

A PROSPECTIVE EVALUATION OF THE RADIOGRAPHIC EFFICACY OF ETANERCEPT IN PATIENTS WITH RHEUMATOID ARTHRITIS OR PSORIATIC ARTHRITIS.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,821 (actual)
• Sponsor: Pfizer · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

It is known from the COMET-trial that patients who start Enbrel treatment early have a great chance of reaching clinical remission and radiographic nonprogression. It is still unclear, however, how many patients with early arthritis achieve remission and radiographic nonprogression under the conditions of routine rheumatologic care and the local recommendations of Enbrel treatment (pre-treatment of at least 2 DMARDs, one of them MTX). Therefore, no robust x-ray data are available to show/demonstrate * the average extent of x-ray damage in routine patients on Enbrel outside clinical studies. * if the outstanding effect on structural damage of Enbrel can be reproduced in routine practice. * that the 'Silent Progressor' is an issue relevant not only in clinical trials, but also for day-to-day decision making. * the optimal onset of Enbrel treatment in the course of the disease to prevent radiographic damage

Detailed description

Non-interventional study: subjects to be selected according to the usual clinical practice of their physician

Conditions

• Rheumatoid Arthritis
• Psoriasis Arthritis

Interventions

Type	Name	Description
DRUG	Etanercept	The patients will be treated in accordance with the requirements of the labelling of Enbrel® in Germany. The dosage and duration of therapy is to be determined by the physician to meet the patients' individual needs for treatment.
DRUG	Etanercept	The patients will be treated in accordance with the requirements of the labelling of Enbrel® in Germany. The dosage and duration of therapy is to be determined by the physician to meet the patients' individual needs for treatment.

Timeline

• Start date: 2012-02-01
• Primary completion: 2018-03-01
• Completion: 2018-03-01
• First posted: 2012-06-20
• Last updated: 2019-08-16
• Results posted: 2019-08-16