NCT01615991

Multicentre Canadian Study to Measure the Safety and Efficacy of Radiosynoviorthesis

Multicentre Canadian Study to Measure the Safety and Efficacy of Synoviorthesis Performed With Yttrium-90 or Rhenium-186 Sulfide

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 300 (actual)
• Sponsor: Centre de recherche du Centre hospitalier universitaire de Sherbrooke · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Radiation synovectomy by intra-articular injection of beta-emitting radionuclides is considered a reliable and easy-to-perform therapy without harmful side-effects for the treatment of inflammatory joint disease in many countries. The goal of this study is to demonstrate Yttrium-90 citrate colloid or Rhenium-186 sulfide synovectomy are appropriate therapeutic interventions in patients with persistent active synovitis of a joint (characterized by pain, tenderness, and effusion) which is resistant to systemic therapy and intra-articular corticosteroid injections. The primary objective will be to assess the safety of an intra-articular administration of Yttrium-90 citrate colloid or Rhenium-186 sulfide. The secondary objective will be to assess the efficacy on synovitis.

Conditions

• Arthritis

Interventions

Type	Name	Description
DRUG	Radiosynoviorthesis	Intraarticular administration from 111 to 222 Mbq yttrium-90 per joint

Timeline

• Start date: 2012-05-31
• Primary completion: 2017-12-31
• Completion: 2018-12-31
• First posted: 2012-06-11
• Last updated: 2021-04-12

Locations

9 sites across 1 country: Canada