NCT01613066

Intra-bone Cord Blood Transplantation in Patients With Haematological Malignancies

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Ospedale Santa Croce-Carle Cuneo · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Cord blood (CB) from an unrelated donor is increasingly used an alternative source of hematopoietic stem cells for adults with hematologic malignancies who lack an HLA-matched donor. However, the utilization of single-unit CB for transplantation of adult patients has been impeded by the low number of nucleated cells available from individual CB units. Direct intrabone CB injection (IBCBi) has been recently investigated as a solution to cell dose problem in adults, with the aims of minimizing non-specific loss of progenitors. We set up a phase I-II study to assess the safety and efficacy of CB transplantation by IBCBi in adult patients with advanced or high-risk hematological malignancies

Conditions

• High Risk Haematological Malignancies
• Advanced Haematological Malignancies

Interventions

Type	Name	Description
PROCEDURE	Intrabone Allogeneic Transplant	Unrelated single unit intrabone cord blood transplantation

Timeline

• Start date: 2008-11-01
• Primary completion: 2012-11-01
• Completion: 2013-05-01
• First posted: 2012-06-06
• Last updated: 2012-06-06

Locations

1 site across 1 country: Italy