NCT01612403

Study the Effect of Oral Zinc Supplementation on High Molecular Weight Zinc Binding Protein in Semen

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 37 (actual)
• Sponsor: mahmoud hussein hadwan · Academic / Other
• Sex: Male
• Age: 27 Years – 35 Years
• Healthy volunteers: Not accepted

Summary

There are several causes leading to male infertility, like oxidative stress, and nutritional deficiency of trace elements like zinc. Zinc in human seminal plasma was divided into three types of ligands which are high (HMW), intermediate (IMW), and low molecular weight ligands (LMW). The present study was conducted to study the effect of Zn supplementation on the quantitative and qualitative characteristics of semen along with Zinc Binding Protein levels in semen of patients with asthenozoospmia.

Detailed description

Elevation of ROS levels lead to an increase the oxidation of HMW-Zn binding proteins in seminal plasma of asthenozoospermic subjects. Zinc supplementation restores HMW-Zn% in seminal plasma of asthenozoospermic subjects to normal value. LMW-Zn% is elevated in seminal plasma of asthenozoospermic patients. It may be because increment the levels of semenogelin in seminal plasma of asthenozoospermic subjects. Zinc supplementation elevates LMW-Zn% in seminal plasma of asthenozoospermic subjects to more than normal value, this may be because of its enhancement of the synthesis of metallothioneins (Low molecular weight zinc binding protein).

Conditions

• Asthenozoospermia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	zinc sulfate	every participant took two capsules of zinc sulfate per day for three months (each one 220mg)

Timeline

• Start date: 2011-07-01
• Primary completion: 2012-04-01
• Completion: 2012-04-01
• First posted: 2012-06-05
• Last updated: 2012-06-06

Locations

2 sites across 1 country: Iraq