Trials / Completed
CompletedNCT01609803
Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma
Tissue Microarray Studies of the 12q13-q14 Amplicon in Alveolar Rhabdomyosarcoma
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 99 (actual)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- 21 Years
- Healthy volunteers
- Not accepted
Summary
This research trial studies protein expression in tissue samples from younger patients with rhabdomyosarcoma. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
Detailed description
PRIMARY OBJECTIVES: I. To investigate (in two stages) which proteins are overexpressed in association with 12q13-q14 amplification by applying fluorescence in situ hybridization (FISH) and immunohistochemical (IHC) assays to a panel of alveolar rhabdomyosarcomas (ARMS) cases organized into tissue microarrays. OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed for 12q13-q14 frequency and protein overexpression by FISH and IHC.
Conditions
- Alveolar Childhood Rhabdomyosarcoma
- Embryonal Childhood Rhabdomyosarcoma
- Previously Treated Childhood Rhabdomyosarcoma
- Previously Untreated Childhood Rhabdomyosarcoma
- Recurrent Childhood Rhabdomyosarcoma
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | laboratory biomarker analysis | Correlative studies |
Timeline
- Start date
- 2012-06-01
- Primary completion
- 2016-05-01
- Completion
- 2016-05-01
- First posted
- 2012-06-01
- Last updated
- 2016-05-18
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT01609803. Inclusion in this directory is not an endorsement.