NCT01609426

Factors of Steroid Dependency in Idiopathic Nephrotic Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 351 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 6 Months – 16 Years
• Healthy volunteers: Not accepted

Summary

The primary purpose of the study is to identify the factors of steroid dependency in childhood idiopathic nephrotic syndrome. The steroid dependency is defined by a relapse of nephrotic syndrome within the 3 weeks that follow the withdrawal of steroid therapy after the first manifestation. Different clinical and biological factors will be analyzed: age of first manifestation, delay of remission, ethnicity, and preceding viral infection, geolocalization in the Parisian area, genoprevalence of herpes viruses and polymorphisms in the genes involved in the response to steroid therapy.

Detailed description

Patients with a steroid dependent nephrotic syndrome will be compared to those with a non steroid dependent form of nephrotic syndrome at the end of the first manifestation. An additional blood volume will be sampled in patients and controls during a scheduled biological check-up for the initial disease. Genetics factors will be checked using a DNA chips devoted to the response to steroid therapy and viral genome of EBV, CMV, HHV7 will be searched for using PCR reaction in total blood DNA extract.

Conditions

• Idiopathic Nephrotic Syndrome

Interventions

Type	Name	Description
GENETIC	DNA chip dedicated to the pharmacogenetic of steroids	direct DNA extraction from peripheral blood cells

Timeline

• Start date: 2012-09-01
• Primary completion: 2016-06-01
• Completion: 2016-06-01
• First posted: 2012-06-01
• Last updated: 2017-03-27

Locations

1 site across 1 country: France