NCT01608958

IV vs IM Oxytocin in the Third Stage of Labor for Prevention of Postpartum Hemorrhage

Intravenous and Intramuscular Administration of Oxytocin in the Third Stage of Labor for Prevention of Postpartum Hemorrhage

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 653 (actual)
• Sponsor: Gynuity Health Projects · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Accepted

Summary

The study will evaluate whether prophylactic oxytocin administered in the third stage of labor via IV infusion results in a lower mean blood loss compared to IM injection.

Detailed description

The study will compare the effect of IV infusion and IM oxytocin administration on the proportion of women who experience blood loss greater than or equal t 350 ml, the proportion of women who experience blood loss greater than or equal to 500 ml, side effects, adverse events and change in hemoglobin pre- to post-delivery. It will also assess whether a bleeding history questionnaire can identify women at risk for excessive bleeding and help to define the distribution of bleeding scores among women with and without excessive bleeding.

Conditions

• Postpartum Hemorrhage

Interventions

Type	Name	Description
DRUG	Oxytocin	10 IU oxytocin in 500 ml infusion
DRUG	Oxytocin	10 IU oxytocin IM injection

Timeline

• Start date: 2012-05-01
• Primary completion: 2012-11-01
• Completion: 2012-12-01
• First posted: 2012-05-31
• Last updated: 2016-03-28

Locations

3 sites across 3 countries: Ecuador, Turkey (Türkiye), Vietnam