NCT01607996

Effect of Epidural Anesthesia on Pancreatic Perfusion and Clinical Outcome in Patients With Severe Acute Pancreatitis

Phase 1 Study of Epidural Anesthesia on Pancreatic Perfusion and Clinical Outcome in Patients With Severe Acute Pancreatitis

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: University Hospital, Geneva · Academic / Other
• Sex: All
• Age: 16 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to evaluate the safety, the potential beneficial effect of epidural anesthesia on pancreatic perfusion and clinical outcome of patients with severe acute pancreatitis.

Detailed description

High mortality in severe acute pancreatitis (AP) is linked to necrosis of the gland. Animal studies showed that epidural anesthesia (EA) restores pancreatic microcirculation and decreases the severity of AP. The aim of the study is to evaluate the safety of EA, its effect on pancreatic perfusion and clinical outcome of patients with AP.

Conditions

• Severe Acute Pancreatitis

Interventions

Type	Name	Description
PROCEDURE	Epidural anesthesia	Epidural will be performed using carbostesin (0.1%), fentanyl (2 microg/ml) administered continuously at a rate of 6 to 15 ml/hour
DRUG	Patient controlled intravenous analgesia	Fentanyl 10 microg/ml at continuous flow of 10 to 20 microg/hour

Timeline

• Start date: 2005-07-01
• Primary completion: 2010-08-01
• Completion: 2011-11-01
• First posted: 2012-05-30
• Last updated: 2012-05-30

Locations

1 site across 1 country: Switzerland