NCT01604642

Role of Activin A (ActA) in the Human Cancer Cachexia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of the investigators study is to investigate the role of a hormone named Activin A (ActA) in the development of the skeletal muscle atrophy caused by cancer. According to the investigators hypothesis, ActA could be released by the tumor and activate a muscle atrophy gene program. To answer this question, the investigators plan first to compare circulating levels of ActA in cancer patients with and without cachexia. In a second step, the investigators would like to assess whether ActA circulating levels are predictive for the development of cachexia and short survival.

Conditions

• Colorectal Cancer
• Lung Cancer

Interventions

Type	Name	Description
OTHER	blood tests and muscular biopsies	blood tests and muscular biopsies

Timeline

• Start date: 2012-05-01
• Primary completion: 2014-03-01
• Completion: 2016-01-01
• First posted: 2012-05-24
• Last updated: 2018-04-02

Locations

1 site across 1 country: Belgium