NCT01598025

Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLACompatible Donor

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: Memorial Sloan Kettering Cancer Center · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

Approximately 30% of patients who are candidates for bone marrow transplants do not have an HLA-matched, or close to matched, donor available. For this reason, doctors have been testing ways to make transplants from HLA-partially matched donors as safe and effective as transplants from HLA-matched donors. This study is being done to test the safety and the treatment results of a specific kind of transplant. In this transplant, blood from two donors will be used. Each donor will share one half of your HLA type. Blood from both donors will be transplanted at the same time.

Conditions

• Acute Leukemia
• Chronic Leukemia
• Myelodysplastic Syndrome
• Non-Hodgkins Lymphoma

Interventions

Type	Name	Description
RADIATION	total-body irradiation (TBI)
DRUG	thiotepa
DRUG	fludarabine phosphate
DRUG	melphalan
BIOLOGICAL	anti-thymocyte globulin
PROCEDURE	allogeneic hematopoietic stem cell transplantation
BIOLOGICAL	peripheral blood stem cell transplantation
OTHER	laboratory biomarker analysis

Timeline

• Start date: 2012-05-02
• Primary completion: 2017-10-16
• Completion: 2017-10-16
• First posted: 2012-05-15
• Last updated: 2018-08-09
• Results posted: 2018-04-17

Locations

1 site across 1 country: United States