NCT01597427

Reduction of Pulmonary Artery Pressure in Patients Subjected to Cardiac Surgery

Intravenous Clonidine Does Not Reduce Pulmonary Artery Pressure in Patients Subjected to Cardiac

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 29 (actual)
• Sponsor: Federal University of São Paulo · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to assess the ability of clonidine to reduce the mean pulmonary artery pressure in patients with pulmonary hypertension subjected to cardiac surgery.

Detailed description

Prospective, clinical-interventionist, randomized, and double-blind study. Patients with group 2 pulmonary hypertension will be included and subjected to cardiac surgery with extracorporeal circulation. Mean pulmonary artery pressure and the doses of dobutamine and sodium nitroprusside will be assessed four times: before (T0) administration of 2 μg/kg of intravenous clonidine or a placebo, 30 minutes after the onset of treatment (T1), immediately after extracorporeal circulation (T2), and 10 minutes after the injection of protamine (T3).

Conditions

• Anesthesia

Interventions

Type	Name	Description
DRUG	Clonidine	Administration of 2 μg/kg of intravenous clonidine
DRUG	Placebo	Injection of placebo solution.

Timeline

• Start date: 2009-03-01
• Primary completion: 2011-04-01
• Completion: 2012-03-01
• First posted: 2012-05-14
• Last updated: 2012-05-14

Locations

1 site across 1 country: Brazil