NCT01595399

Atropine Versus no Atropine for Neonatal Rapid Sequence Intubation

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: University of Manitoba · Academic / Other
• Sex: All
• Age: 1 Day – 2 Months
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare heart rate in infants who receive atropine as a part of their medication before intubation to those who do not. To be able to find out , we need to divided babies into 2 groups; group 1 : receives atropine + sedation + muscle relaxant group 2 : receives water or saline ( placebo group) + sedation + muscle relaxant Then we need to compare heart rate during intubation and duration of intubation between the 2 groups.

Detailed description

We hypothesize that premedication for intubation with fentanyl and succinylcholine alone will maintain equal stability of heart rate and oxygen saturation without a prolongation of time to completion of intubation when compared to a protocol using atropine, fentanyl and succinylcholine. In order to answer this question we plan to undertake a prospective randomized double blinded control trial of use of atropine as an adjunct for elective intubation of infants less than 46 weeks postmenstrual age.

Conditions

• Bradycardia
• Hypoxemia

Interventions

Type	Name	Description
DRUG	atropine	Atropine 0.02 mg/kg IV
DRUG	Placebo	an equivalent volume of normal saline to atropine IV

Timeline

• Start date: 2012-04-01
• Primary completion: 2014-06-01
• Completion: 2014-06-01
• First posted: 2012-05-10
• Last updated: 2013-09-24

Locations

1 site across 1 country: Canada