NCT01590914

Brain Activation in Response to Appetitive Cues Pre- and Post- Bariatric Surgery

Brain Activation in Response to Appetite Cues Pre- and Post- Bariatric Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: New York Obesity and Nutrition Research Center · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Utilizing fMRI, this study will examine changes in BOLD signal as a proxy measure of brain activation in response to highly palatable (high energy density \[kcal/g\]), less palatable and non-food stimuli in severely obese women pre, 1 month post and 3 months post undergoing bariatric surgery (in surgery patients) and at equivalent times for control groups in fed and fasted conditions at each time point. Two surgical groups: (i) laparoscopic Roux-en-Y gastric bypass (RYGB) and (ii) gastric banding (GB) will be compared with two control groups: (i)those enrolled on a 3-month formula weight loss program or (ii) those who qualify, but do not undergo bariatric surgery, and receive no weight loss treatment.

Conditions

• Obesity

Interventions

Type	Name	Description
PROCEDURE	Fed Condition	Subjects will consume a 250ml liquid test meal (250kcal) before undergoing a 40min fMRI scan to assess the BOLD signal responses to visual and auditory responses to food and non-food cues.
PROCEDURE	Fasted Condition	Subjects will consume a 250ml control (water) before undergoing a 40min fMRI scan to assess BOLD signal response to visual and auditory food and non-food cues

Timeline

• Start date: 2008-01-01
• Primary completion: 2014-01-01
• Completion: 2014-01-01
• First posted: 2012-05-03
• Last updated: 2024-08-27

Locations

2 sites across 1 country: United States