NCT01588886

Proton Pump Inhibitor Use is Associated With High Risk of Pneumonia in Chronic Kidney Disease Patients

Institute of Emergency and Critical Care Medicine , School of Yang-Ming University

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 9,000 (actual)
• Sponsor: Far Eastern Memorial Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Chronic kidney disease is a severe medical problem in Taiwan public health issue, which the highest incidence and prevalence rate in the world.Proton pump inhibitors may increase the risk of pneumonia appearance, which were caused by profound irreversible gastric acid suppression. The study purpose was to characterize difference of developing pneumonia in chronic kidney disease of prior use proton pump inhibitors.

Detailed description

The study used data from Taiwan Health Insurance Research Database; the investigators conducted a population-based cohort study in Taiwan. Case consisted of all patients who had a first diagnosis of chronic kidney disease for the period between 1997 and 2008. The investigators utilized the use of Proton pump inhibitor from chronic kidney disease patients.

Conditions

• Chronic Kidney Disease
• Pneumonia

Timeline

• Start date: 2012-03-01
• Primary completion: 2012-06-01
• Completion: 2015-08-01
• First posted: 2012-05-01
• Last updated: 2017-02-16