NCT01588847

Anesthesia and Cancer Recurrence im Malignant Melanoma

Long-term Outcome After Radical Lymph Node Dissection of Malignant Melanoma. Comparison Between Regional Versus General Anesthesia With Respect to Impact of Perioperative Immunoediting and Validation of New Potential Predictive Biomarkers

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 230 (estimated)
• Sponsor: University Hospital Muenster · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Studies in animals and retrospective studies in humans show that regional anesthesia reduces metastatic cancer dissemination. The investigators hypothesize that in patients suffering from malignant melanoma who have to undergo radical inguinal lymph node dissection immune function will be less compromised and long term survival will be superior when spinal anesthesia is compared to general anesthesia.

Detailed description

Results of basic science indicate that regional anesthesia prevents perioperative immunosuppression and reduces postoperative metastatic cancer dissemination. If this would occur in humans, optimised anesthetic management might improve long-term outcome after cancer surgery.

Conditions

• Malignant Melanoma

Interventions

Type	Name	Description
PROCEDURE	Spinal anesthesia with Bupivacaine hyperbar 0.5 %	Spinal anesthesia with Bupivacaine hyperbar 0.5 %
PROCEDURE	General anesthesia with Sufentanil, Propofol and Rocuronium and Sevoflurane	General anesthesia with Sufentanil, Propofol and Rocuronium and Sevoflurane

Timeline

• Start date: 2012-03-01
• Primary completion: 2019-03-01
• Completion: 2019-03-01
• First posted: 2012-05-01
• Last updated: 2014-12-11

Locations

1 site across 1 country: Germany