NCT01588418

Acute Effect of Exenatide on Brain Glucose Metabolism

Effect of Exenatide on Brain Glucose Uptake in Relations to Pancreatic, Adipose Tissue, and Hepatic Function

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: The University of Texas Health Science Center at San Antonio · Academic / Other
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This research study will examine brain glucose metabolism after an overnight fast to determine the effect of exenatide on brain glucose metabolism and lipid metabolism.

Detailed description

This study will elucidate if exenatide has an effect on brain glucose metabolism. This will be accomplished by measuring the rate of glucose binding in various brain regions by Positron Emission Tomography (PET) after glucose load with exenatide injection and compare it with placebo injection measured in the same subject. The changes will be compared with peripheral and hepatic glucose metabolism and lipolysis.

Conditions

• Impaired Glucose Tolerance (IGT)
• Diabetes

Interventions

Type	Name	Description
DRUG	Exenatide	Exenatide (5mcg) was administered in random order 30 min before OGTT-PET study, crossover study
DRUG	Placebo	Placebo was administered in random order 30 min before OGTT-PET study in the same subject

Timeline

• Start date: 2010-07-01
• Primary completion: 2015-07-01
• Completion: 2015-07-01
• First posted: 2012-05-01
• Last updated: 2017-11-24
• Results posted: 2017-05-25

Locations

1 site across 1 country: United States