NCT01586000

A Dose-finding Study to Evaluate the Effect of a Contraceptive Vaginal Ring, Releasing Nestorone® and Estradiol, on Cycle Control, Ovulation Inhibition, and Pharmacokinetics in Normal Cycling Women

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 197 (actual)
• Sponsor: Kimberly Myer · Academic / Other
• Sex: Female
• Age: 18 Years – 39 Years
• Healthy volunteers: Accepted

Summary

This clinical trial is an experimental research study using a potential new form of birth control. Clinical trials include people who volunteer to take part in a study. Take your time to decide if you want to be part of this experimental research study. If you want to know more about this study first, ask the study doctor or study site staff. The investigators can also give you the study information written for doctors and clinic staff.

Conditions

• Suppression of Ovulation

Interventions

Type	Name	Description
DRUG	10 µg/day E2 with NES 200® µg/day	10 µg/day E2 with NES 200® µg/day delivered by CVR continuously for 6 months (180 days)
DRUG	20 µg/day E2 with NES 200® µg/day	20 µg/day E2 with NES 200® µg/day delivered by CVR continuously for 6 months (180 days)
DRUG	40 µg/day E2 with NES 200® µg/day	40 µg/day E2 with NES 200® µg/day delivered by CVR continuously for 6 months (180 days)

Timeline

• Start date: 2012-03-01
• Primary completion: 2015-05-01
• Completion: 2015-05-01
• First posted: 2012-04-26
• Last updated: 2025-12-08
• Results posted: 2025-12-08

Locations

8 sites across 1 country: United States