NCT01585376

Studying Genes in Samples From Younger Patients With Rhabdomyosarcoma

Study Recurrency Testing of Mutations Identified in WGS of Pediatric Rhabdomyosarcoma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 58 (estimated)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and find biomarkers related to cancer. It may also help doctors find better ways to treat cancer. PURPOSE: This research trial studies genes in samples from younger patients with rhabdomyosarcoma.

Detailed description

OBJECTIVES: * To obtain a larger cohort of rhabdomyosarcoma samples (alveolar and embryonal) to establish a more accurate estimate of the frequency of particular genetic lesions. * To provide the statistical power to establish an unambiguous connection between focal genetic lesions, histological subtype, and outcome for patients with rhabdomyosarcoma. OUTLINE: DNA samples are analyzed in solid and liquid phase for exons of all genes mutated from previous discovery. DNA is then eluted and sequenced by illumina platform.

Conditions

• Sarcoma

Interventions

Type	Name	Description
GENETIC	mutation analysis
GENETIC	nucleic acid sequencing
OTHER	laboratory biomarker analysis

Timeline

• Start date: 2012-04-01
• Primary completion: 2016-05-01
• Completion: 2016-05-01
• First posted: 2012-04-25
• Last updated: 2016-05-18