NCT01583920

Focal Salvage HDR Brachytherapy for the Treatment of Prostate Cancer

Pilot Study of Focal Salvage HDR Prostate Brachytherapy

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Sunnybrook Health Sciences Centre · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Radiation therapy is considered a standard treatment option for the management of localized prostate cancer. Among the 20-30% who recur, a proportion of them will present with an isolated local recurrence, meaning no distant metastases. If left untreated, it may serve as a source for subsequent metastases. Salvage options available for isolated local recurrence include; temporary or permanent implantation of radioactive seeds into the prostate, complete removal of the prostate gland, use of low temperatures to treat the disease, and high frequency ultrasound to treat the disease. There are risks of complications associated with all these treatments, and there is presently no consensus as to which treatment is the best. Therefore, the aim of this pilot study is to look at the feasibility and toxicities of focal treatment of the prostate using temporary implantation of radioactive seeds into the prostate which the investigators hope will be less since the entire prostate is not treated.

Conditions

• Prostate Cancer

Interventions

Type	Name	Description
RADIATION	focal salvage HDR prostate brachytherapy	Treatment will be delivered using 192-Ir HDR afterloading. Dose prescription is 2 fractions of 13.5 Gy each, delivered 1 week apart.

Timeline

• Start date: 2012-07-01
• Primary completion: 2028-07-01
• Completion: 2028-07-01
• First posted: 2012-04-24
• Last updated: 2024-11-27

Locations

1 site across 1 country: Canada