NCT01578382

Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU)

Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU): A Comparison of Martorell HYTILU, Calciphylaxis and Venous Ulcer (Control)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 20 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Martorell hypertensive ischemic leg ulcer is a severe type of skin necrosis (skin infarction) which occurs in long-term hypertensive subjects. Calciphylaxis (calcific uremic arteriolopathy) is a severe type of skin necrosis (skin infarction) which occurs in subjects with end-stage kidney disease or after kidney transplantation.

Detailed description

Comparative study including * 20 consecutive patients with Martorell HYTILU * 10 consecutive patients with Calciphylaxis (calcific uremic arteriolopathy) * 20 patients with venous ulcer The following parameters are measured in the blood serum: White blood count; c-reactive protein; creatinine; calcium (total); free (ionized) calcium; phosphate; albumin; 25-hydroxyvitamin-D; 1-25-dihydroxyvitamin-D; homocysteine; cystatin C alphafetoin, osteoprotegerin; fibroblast growth factor 23 (FGF-23); globular arrest 1 (GLA-1) The following parameters are measured in samples of diseased (necrobiotic) skin: alphafetoin, osteoprotegerin; fibroblast growth factor 23 (FGF-23); globular arrest 1 (GLA-1)

Conditions

• Hypertensive Ischemic Leg Ulcer
• Calciphylaxis

Timeline

• Start date: 2011-09-01
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2012-04-16
• Last updated: 2021-06-18

Locations

1 site across 1 country: Switzerland