NCT01577056

Postprandial Lipid Metabolism in Familial Hypercholesterolaemia:Effects of Fish Oils

Effect of Fish Oil Supplementation on Postprandial Lipid Metabolism in Familial Hypercholesterolaemia

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: The University of Western Australia · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether fish oil supplementation is effective in the treatment of abnormal fat metabolism in subjects with elevated cholesterolaemia.

Detailed description

The use of statin therapy in familial hypercholesterolaemia (FH) is known to reduce cardiovascular risk and is a first line recommendation, however, there is considerable residual risk predicted by the presence of fasting and post-prandial hypertriglyceridaemia. This study will examine the effect of oral n-3 fatty acid ethyl esters supplementation (4g/day, Omacor) on postprandial hypertriglyceridaemia and post-prandial arterial function when administrated to FH patients at increased risk of cardiovascular disease due to their residual fasting hypertriglyceridaemia.

Conditions

• Hypertriglyceridaemia
• Familial Hypercholesterolaemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Fish oil capsule	4g Omega capsule for 12 weeks
DRUG	HMG Coenzyme reductase	All FH subjects are on standard statin treatment during study period

Timeline

• Start date: 2012-04-01
• Primary completion: 2013-12-01
• Completion: 2014-03-01
• First posted: 2012-04-13
• Last updated: 2012-04-13

Locations

1 site across 1 country: Australia