Trials / Completed
CompletedNCT01575535
S0106B Studying Bone Marrow Samples From Women With Acute Myeloid Leukemia
S0106B, Stem Cell Origin in AML: Prognostic and Therapeutic Implications
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 100 (actual)
- Sponsor
- SWOG Cancer Research Network · Network
- Sex
- Female
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of bone marrow from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research trial studies bone marrow samples from women with acute myeloid leukemia.
Detailed description
OBJECTIVES: * Estimate the proportion of acute myeloid leukemia (AMLs) that originate in CD33+ precursors or in which uncontrolled growth is limited to CD33+ precursors. * Explore whether there is an association between the cellular origin of AML (i.e., origination in CD33+ precursors or not) and cytogenetic, molecular, and other patient characteristics. * Explore whether overall survival (OS), event-free survival (EFS), disease-free survival (DFS), response rate (RR), or relapse rate is improved for patients with AMLs that originate in CD33+ precursors or in which uncontrolled growth is limited to CD33+ precursors compared to patients with clonally involved cells not detected. OUTLINE: Archived bone marrow samples are analyzed for CD33+ progenitors, X-chromosome inactivation, and somatic mutations (t(8;21), inv(16), FLT3/ITD, NPM1, CEBPA, KIT) by fluorescence-activated cell sorting, long-term culture in hypoxic condition in cytokine-containing liquid media, and flow cytometry. Results are then compared with each patient clinical data.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | gene expression analysis | |
| OTHER | flow cytometry | |
| OTHER | fluorescence activated cell sorting | |
| OTHER | laboratory biomarker analysis | |
| OTHER | medical chart review |
Timeline
- Start date
- 2012-04-01
- Primary completion
- 2012-05-01
- Completion
- 2012-05-01
- First posted
- 2012-04-11
- Last updated
- 2015-03-06
Source: ClinicalTrials.gov record NCT01575535. Inclusion in this directory is not an endorsement.