NCT01574157

Investigations of the Optimum Serum Bicarbonate Level in Renal Disease.

Investigations of the Optimum Serum Bicarbonate Level in Renal Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 74 (actual)
• Sponsor: VA Office of Research and Development · Federal
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to see if treatment with sodium bicarbonate will lower urine levels of proteins that are indicators of kidney damage in people with diabetes who also have chronic kidney disease.

Detailed description

Diabetic chronic kidney disease (CKD) is a common problem in Veterans and progresses to end-stage renal disease in many people. It is important to identify treatment strategies that will help prevent the progression of CKD to overt kidney failure. The purpose of this study is to see if sodium bicarbonate reduces urinary markers of kidney damage in Veterans with diabetic CKD and normal serum bicarbonate levels.

Conditions

• Chronic Renal Insufficiency
• Diabetes Mellitus

Interventions

Type	Name	Description
DRUG	Sodium bicarbonate	Participants will receive 0.5 meq of sodium bicarbonate per 1 kilogram of lean body weight daily. The total amount will be divided into twice daily doses.
DRUG	Placebo	Participants will receive an identical number of placebo tablets had they been assigned to the intervention. Placebo will be divided into twice daily doses and receive this for six months.

Timeline

• Start date: 2012-11-05
• Primary completion: 2018-05-01
• Completion: 2018-05-01
• First posted: 2012-04-10
• Last updated: 2019-08-28
• Results posted: 2019-08-28

Locations

1 site across 1 country: United States