NCT01572467

Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors

DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: 120 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer. PURPOSE: This research trial is studying genes in tumor samples from younger patients with ovarian or testicular sex cord stromal tumors.

Detailed description

OBJECTIVES: * To assess the role of DICER1 mutations and miRNA pathways in the etiology and progression of ovarian or testicular sex cord stromal tumors. OUTLINE: Archived tumor tissue samples are analyzed for D1CER1 mutation and mRNA expression by reverse-transcriptase polymerase chain reaction (RT-PCR) and laser micro dissector. Results are then correlated with medical data, including age at diagnosis, diagnosis, pathology report, presenting symptoms, family history, treatment, outcome, and length of follow-up, when available.

Conditions

• Childhood Germ Cell Tumor
• Leydig Cell Tumor
• Ovarian Cancer

Interventions

Type	Name	Description
GENETIC	RNA analysis
GENETIC	gene expression analysis
GENETIC	mutation analysis
GENETIC	reverse transcriptase-polymerase chain reaction
OTHER	laboratory biomarker analysis
OTHER	medical chart review

Timeline

• Start date: 2012-04-01
• Primary completion: 2016-07-01
• First posted: 2012-04-06
• Last updated: 2016-07-14