NCT01571804

Pregabalin Reduce the Sevoflurane Requirement

Does Pregabalin Reduce the Sevoflurane Requirement During Laparoscopic Cholecystectomy? Mansoura University Hospitals Experience.

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Mansoura University · Academic / Other
• Sex: Male
• Age: 25 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

Preoperative administration of pregabalin would reduce the end tidal concentration of sevoflurane during laparoscopic cholecystectomy with added beneficial improving of the quality of postoperative analgesia.

Detailed description

laparoscopic cholecystectomy is a painful and stressful surgical procedure. Pregabalin is a lipophilic structural analogue of the inhibitory γ-aminobutyric acid by binding to the presynaptic voltage-gated calcium channels that are widely distributed throughout the central and peripheral nervous system. Pregabalin has anticonvulsant, anxiolytic, sleep-modulating, anti-hyperalgesic, opioid-sparing6 and anti-allodynic properties through inhibition of the release of excitatory neurotransmitters such as glutamate, norepinephrine, serotonin, dopamine and substance P. These unique characteristics make pregabalin as a useful therapeutic for treating neuropathic pain and acute postoperative pain in several models of incisional injury and inflammatory conditions including laparoscopic cholecystectomy.

Conditions

• Elective Laparoscopic Cholecystectomy
• Sevoflurane Anesthesia

Interventions

Type	Name	Description
DRUG	Placebo	to receive two identical placebo capsules 1 hr before surgery
DRUG	pregabalin	one capsule of pregabalin 150 mg and one placebo capsule 1 hr before surgery
DRUG	pregabalin	two capsules of pregabalin 150 mg 1 hr before surgery

Timeline

• Start date: 2011-12-01
• Primary completion: 2012-02-01
• Completion: 2012-03-01
• First posted: 2012-04-05
• Last updated: 2012-05-07

Locations

1 site across 1 country: Egypt