NCT01570452

Matrilysin Expression in Different Stages of Colorectal Tumors

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 38 (actual)
• Sponsor: University of Roma La Sapienza · Academic / Other
• Sex: All
• Age: 40 Years – 83 Years
• Healthy volunteers: Accepted

Summary

Matrix metalloproteinases (MMPs) have been shown to be involved in cancer biology. Significant expression of MMP-7 (matrilysin) in colorectal cancer is mainly associated with metastatic disease even though it is expressed in most tumor states. Our purpose is to analyse MMP-7 in bowel and lymph nodes of different tumor stages and to evaluate its expression as a potential biomarker of cancer disease in patients surgically treated for benign and malignant colorectal tumors. Tumoral tissue, lymph nodes and serum samples from recruited Patients plus serum samples from healthy volunteers are analysed for matrilysin expression by histology, immunohistochemistry, ELISA and Western blotting. If Matrilysin increases with increasing dysplasia and cancer disease stage in tumor tissue as well as in the regional lymph nodes it might be used as a complement in investigating suspected locally advanced cancer.

Conditions

• Colorectal Cancer Stage 0
• Colorectal Cancer Stage I
• Colorectal Cancer Stage II
• Colorectal Cancer Stage III
• Colorectal Cancer Stage IV

Interventions

Type	Name	Description
PROCEDURE	colonic or colorectal resection	standard laparotomic resection of colon-rectum including right hemicolectomy, left hemicolectomy, sigmoidectomy, anterior resection

Timeline

• Start date: 2005-09-01
• Primary completion: 2008-09-01
• Completion: 2012-02-01
• First posted: 2012-04-04
• Last updated: 2012-04-04

Locations

1 site across 1 country: Italy