NCT01564680

Lornoxicam vs. Paracetamol After Lower Abdominal Surgery

Intravenous Lornoxicam is More Effective Than Paracetamol as a Supplemental Analgesic After Lower Abdominal Surgery; A Randomized Controlled Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Imam Abdulrahman Bin Faisal University · Academic / Other
• Sex: All
• Age: 18 Years – 69 Years
• Healthy volunteers: Not accepted

Summary

Background: The aim of this prospective, randomized, double-blind study is to determine the most effective supplemental analgesic, paracetamol or lornoxicam for postoperative pain relief after lower abdominal surgery. Methods: Sixty patients scheduled for lower abdominal surgery under general anesthesia were randomly allocated to receive either isotonic saline (Control group), intravenous paracetamol 1 g every 6 h (Paracetamol group) or lornoxicam 16 mg then 8 mg after 12 h (Lornoxicam group). Additionally pain was treated postoperatively using morphine patient-controlled analgesia. Postoperative pain scores measured by the verbal pain score (VPS), morphine consumption and the incidence of side effects were measured at 1, 2, 4, 8, 12 and 24 hours postoperatively.

Conditions

• Postoperative Pain

Interventions

Type	Name	Description
OTHER	placebo	normal saline
DRUG	Paracetamol	IV paracetamol infusion
DRUG	Lornoxicam	16 mg at skin closure and 8 mg 12 hours postoperative

Timeline

• Start date: 2009-03-01
• Primary completion: 2011-03-01
• Completion: 2011-03-01
• First posted: 2012-03-28
• Last updated: 2012-03-28

Locations

1 site across 1 country: Saudi Arabia