NCT01563770

Cardiovascular Effects of Salvia Miltiorrhiza Extract (Danshen)

A Double Blind, Randomized Placebo-controlled Cross-over Study on the Cardiovascular Effects of Salvia Miltiorrhiza Extract (Danshen) in Patients With Hypertension and Hyperlipidemia.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Rationale: Extracts of the plant Salvia miltiorrhiza (Danshen) have been used as traditional Chinese medicine in the treatment of cardiovascular diseases, such as angina pectoris and myocardial infarction. Several preclinical studies point towards promising effects of Danshen on risk factors of atherosclerotic cardiovascular diseases, such as hyperlipidemia and hypertension. Objective: Our primary objective is to determine the effect of Salvia miltiorrhiza extract (Danshen) on hyperlipidemia. Secondary objective is to investigate the effect of Danshen on hypertension. Further objectives are to determine its effect on endothelial function, oxidative stress, inflammation, hemostasis and hemorheology, and on insulin sensitivity.

Conditions

• Dyslipidemias
• Hypertension
• Vasodilation
• Oxidative Stress
• Inflammation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Salvia miltiorrhiza extract	3 capsules of 500 mg Salvia miltiorrhiza extract, twice daily for four consecutive weeks
DIETARY_SUPPLEMENT	Placebo	3 placebo capsules, twice daily for four consecutive weeks

Timeline

• Start date: 2012-04-01
• Primary completion: 2012-12-01
• Completion: 2013-03-01
• First posted: 2012-03-27
• Last updated: 2012-05-24

Locations

1 site across 1 country: Netherlands