NCT01562145

Elevated Plasma Levels of TIMP-1 in Patients With Rotator Cuff Tear

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 34 (actual)
• Sponsor: University Hospital, Linkoeping · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

The aim of the study was to investigate the levels of matrixmetalloproteinases and their inhibitors in blood samples from patients with rotator cuff tears and compare with blood samples from healthy matched controls.

Detailed description

Background: Extracellular matrix remodeling is altered in rotator cuff tears, partly due to altered expression of matrix metalloproteinases (MMPs) and their inhibitors. It is unclear if this altered expression can be traced as changes in plasma protein levels. We measured the plasma level of MMPs and their tissue inhibitors (TIMPs) in patients with rotator cuff tears. Material and methods: Blood samples were collected from 17 patients, median 61 (range 39-77) years, with sonographically verified rotator cuff tears (partial- or full-thickness). These were compared with 16 gender and age matched control persons with sonographically intact rotator cuffs. Plasma levels of MMPs and TIMPs were measured simultaneously using Luminex technology.

Conditions

• Rotator Cuff Tear

Interventions

Type	Name	Description
PROCEDURE	Blood sampling	Four mL venous blood samples were collected from all study participants after inclusion

Timeline

• Start date: 2009-01-01
• Primary completion: 2010-02-01
• Completion: 2010-02-01
• First posted: 2012-03-23
• Last updated: 2012-03-26

Locations

1 site across 1 country: Sweden