NCT01559285

Effects of Epidurally Administered Ropivacaine Concentration on the Hemodynamic Parameters

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Pusan National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

In this trial, the investigators intend to examine whether the concentration of local anesthetics during epidural analgesia could be modulating factor for change of hemodynamics in patients undergoing major upper abdominal surgery.

Detailed description

One hundred and twenty patients scheduled for major abdominal surgery under TEA combined general anesthesia were randomized in a double-blinded method to receive one of three different concentration study solutions in 8 ml of volume after the induction of anesthesia: 0.75% ropivacaine (60 mg), 0.375% ropivacaine (30 mg), or 0.2% ropivacane (16 mg). In each group, the patients were divided into two subgroups at the age of 60 to perform age based analysis. The acquired hemodynamic data after administration of epidural loading dose were compared and analyzed between young and elderly groups in each group.

Conditions

• Epidural Anesthesia
• Ropivacaine Concentration
• Hemodynamics

Interventions

Type	Name	Description
DRUG	0.75% ropivacaine concentration	0.75% ropivacaine 8ml was injected epidurally after induction of general anesthesia
DRUG	0.375% ropivacaine concentration	0.375% ropivacaine 8ml was injected epidurally after induction of general anesthesia
DRUG	0.2% ropivacaine concentration	0.2% ropivacaine 8ml was injected epidurally after induction of general anesthesia

Timeline

• Start date: 2011-11-16
• Primary completion: 2013-04-19
• Completion: 2013-04-19
• First posted: 2012-03-21
• Last updated: 2017-08-29

Locations

1 site across 1 country: South Korea