NCT01559155

Role of Proteasomes in a Dermatological Autoimmune Disease: Bullous Pemphigoid

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 14 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The primary objective of this study is to describe and compare plasmatic anti-proteasome auto-antibody concentrations among three distinct groups: (1) patients suffering from bullous pemphigoide; (2) patients suffering from other dermatological auto-immune diseases; (3) an elderly control group.

Detailed description

The secondary objectives of this study are: To compare the following parameters between the 3 groups: * plasmatic proteasome concentrations * plasmatic proteasome proteolytic activity To explore the potential relationships between: * plasmatic proteasome concentrations * plasmatic proteasome proteolytic activity * plasmatic anti-proteasome auto-antibody concentrations * measures of disease severity for dermatological auto-immune diseases To characterize plasmatic anti-proteasome auto-antibodies in patients suffering from bullous pemphigoide and other dermatological auto-immune diseases (other bullous auto immune diseases: pemphigus, cutaneous lupus, ...). To characterize the expression and the activity of proteasomes in skin samples, in plasma and in circulating mononuclear cells in patients with bullous pemphigoide.

Conditions

• Pemphigoid, Bullous
• Pemphigus
• Lupus Erythematosus, Cutaneous

Timeline

• Start date: 2013-11-05
• Primary completion: 2015-06-09
• Completion: 2015-06-09
• First posted: 2012-03-21
• Last updated: 2018-05-11

Locations

1 site across 1 country: France