NCT01558427

Non-systemic Treatment for Patients With Low-volume Metastatic Prostate Cancer

Salvage Treatment or Active Clinical Surveillance for Oligometastatic Prostate Cancer: a Randomized Phase II Trial

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 62 (actual)
• Sponsor: University Hospital, Ghent · Academic / Other
• Sex: Male
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Prostate cancer patients diagnosed with a biochemical recurrence and limited metastases are conventionally treated with androgen deprivation therapy. However, in patients with limited metastatic load, the time to progression might be. Subsequently, active surveillance of these patients until progression might defer the start of androgen deprivation therapy (ADT) for several months to years. As an alternative, salvage treatment of the limited number of metastases with either surgery or radiotherapy might postpone the start of ADT even longer. The current trial hypothesizes that ADT might be deferred longer following salvage treatment as compared to active surveillance.

Conditions

• Prostate Cancer

Interventions

Type	Name	Description
PROCEDURE	Surveillance	Active clinical surveillance
PROCEDURE	Salvage treatment	Surgical removal of metastases, or stereotactic body radiotherapy of metastases.

Timeline

• Start date: 2012-08-01
• Primary completion: 2018-08-15
• Completion: 2023-08-15
• First posted: 2012-03-20
• Last updated: 2023-09-05

Locations

1 site across 1 country: Belgium