NCT01554345

Effect of Vitamin E+Selenium on Kidney Function in Controlled Hypotension

Assessment of Preventive Effect of Vitamin E +Selenium on Acute Kidney Injury Through NGAL in Patients Undergoing Controlled Hypotension During Neurosurgery Operations

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Tehran University of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether Kidney injury happens in controlled hypotension during brain operations by using Neutrophil Gelatinase Associated Lipocalin ELISA Kit and if so, does VitaminE+Selenium prevent it

Detailed description

NGAL(Neutrophil Gelatinase Associated Lipocalin) is a 25KD protein which bounds with Gelatinase in Neutrophil granules.It is also expressed in epithelial cells of kidney tubules.NGAL increases in ischemic and toxic injuries of kidney. During controlled hypotension in brain operations injury to the kidneys might occur . This study is designed to assess this possibility and evaluate the effect of VitaminE+Selenium on prevention of this problem

Conditions

• Acute Kidney Injury

Interventions

Type	Name	Description
DRUG	vitamin E +Selenium	vitamin E 400 IU once 8 hrs before operation selenium 150 mic once 8 hrs before operation

Timeline

• Start date: 2011-06-01
• Primary completion: 2012-08-01
• First posted: 2012-03-14
• Last updated: 2012-03-14

Locations

1 site across 1 country: Iran