NCT01546090

Effect of Alprazolam on the Success of Inferior Alveolar Nerve (IAN) Block

Effect of Preoperative Alprazolam on the Success of Inferior Alveolar Nerve Block for Teeth With Irreversible Pulpitis

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Isfahan University of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this prospective, randomized, double-blind, placebo-controlled study is to evaluate the effect of preoperative administration of alprazolam on the success of the IAN block for teeth with irreversible pulpitis.

Detailed description

Sixty patients diagnosed with irreversible pulpitis of a mandibular molar randomly receive, in a double-blind manner, identical capsules of either 0.50 mg alprazolam or placebo 45 minutes before the administration of a conventional IAN block. Access is begun 15 minutes after completion of the IAN block, and all patients profound lip numbness. Success is defined as no or mild pain based on visual analog scale recordings during access preparation and initial instrumentation.

Conditions

• Inferior Alveolar Nerve Block Failure

Interventions

Type	Name	Description
DRUG	Alprazolam	preoperative administration of an orally 0.50 mg single dose
DRUG	placebo	placebo capsules were filled with starch

Timeline

• Start date: 2011-03-01
• Primary completion: 2011-10-01
• Completion: 2012-02-01
• First posted: 2012-03-07
• Last updated: 2012-03-07

Locations

2 sites across 1 country: Iran