NCT01544959

Postoperative Analgesia Impact of Narcotic Free Anesthesia

The Impact on Postoperative Pain of Substituting Opioids by Beta Blockers for Peroperative Hemodynamic Control in Patients Undergoing Mastectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 84 (estimated)
• Sponsor: Université de Sherbrooke · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The first hypothesis of the study is that substituting fentanyl by esmolol and metoprolol during general anesthesia for patients undergoing mastectomy will result in less pain and less narcotic consumption in the recovery room. The investigators will also verify the impact of that substitution on nausea and vomiting, on the time spent in the recovery room and on chronic postsurgical pain (3 and 6 months). Finally, the investigators will see the impact on breast cancer recurrence 5 years after the surgery.

Conditions

• Pain, Postoperative
• Breast Cancer
• Postoperative Nausea and Vomiting

Interventions

Type	Name	Description
DRUG	fentanyl	Use of esmolol and metoprolol compared to use of fentanyl for hemodynamic control during general anesthesia. At induction, fentanyl (2 mcg/kg) is replaced by esmolol (1 mg/kg). During the case, with a standardised anesthesia, response to surgical stimulation will be medicated either by fentanyl (50 mcg aliquot) or metropolol (2.5 mg), for a maximum of 6 doses. After this, fentanyl will be given unblindly.
DRUG	beta-blocker (esmolol, metropolol)	esmolol is used at induction and lopressor during surgery instead of fentanyl in response to surgical stimulation.

Timeline

• Start date: 2010-01-01
• Primary completion: 2013-01-01
• Completion: 2018-05-01
• First posted: 2012-03-06
• Last updated: 2018-10-24

Locations

1 site across 1 country: Canada