NCT01544829

The Acute Effect of 2 Different Serving Regimens of Theobromine on Physiological Effects

The Acute Effect of 2 Different Serving Regimens of Theobromine on Theobromine Concentration in the Blood & Physiological Effects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Unilever R&D · Industry
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The main aim of this study is to determine whether there is a difference in the physiological effects of theobromine when provided via a single serving compared to multiple servings adding up to the same amount of theobromine provided on a day. This study also aims to study the pharmacokinetics of theobromine after administration once per day versus administration 4 times per day. Hypothesis: the effects on heart rate are less pronounced when a high dose of theobromine is given in 4 smaller doses.

Conditions

• Cardiovascular Diseases

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Theobromine	Single dose of theobromine
DIETARY_SUPPLEMENT	Theobromine	Multiple doses of theobromine
DIETARY_SUPPLEMENT	Placebo	Placebo capsules

Timeline

• Start date: 2012-02-01
• Primary completion: 2012-04-01
• Completion: 2012-06-01
• First posted: 2012-03-06
• Last updated: 2012-12-03

Locations

1 site across 1 country: France