Trials / Completed
CompletedNCT01544569
Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors
Endogenous DNA Transposition in Rhabdoid Tumors
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 50 (estimated)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- 1 Year
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer. PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid tumors.
Detailed description
OBJECTIVES: * To investigate the expression and function of transposons in 50 primary rhabdoid tumors. OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location of transposons. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | DNA analysis | |
| GENETIC | fluorescence in situ hybridization | |
| GENETIC | gene expression analysis | |
| GENETIC | gene mapping | |
| GENETIC | microarray analysis | |
| GENETIC | polymerase chain reaction | |
| GENETIC | protein expression analysis | |
| OTHER | laboratory biomarker analysis | |
| OTHER | medical chart review |
Timeline
- Start date
- 2012-03-01
- Primary completion
- 2016-05-01
- First posted
- 2012-03-06
- Last updated
- 2016-05-18
Source: ClinicalTrials.gov record NCT01544569. Inclusion in this directory is not an endorsement.