NCT01543165

Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic

A Single Center, Prospective Randomized Double-blind Trial: Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 111 (estimated)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

This study is to see whether the combination regimen of ketorolac and nefopam is superior to that of ketorolac and morphine in controlling ureter stone-related acute flank pain.

Detailed description

The balanced analgesia regimen using both ketorolac and morphine is the most effective choice in controlling urolithiasis related acute pain. Previous animal and human studies reported that combination regimen of ketoprofen and nefopam showed synergistic effect in pain control. We hypothesized that using nefopam instead of morphine for ketorolac based combination analgesia will produce similar pain reduction without causing opioid-related side effect.

Conditions

• Renal Colic

Interventions

Type	Name	Description
DRUG	Ketorolac and nefopam balanced analgesia	Sequential intravenous administration of ketorolac and nefopam
DRUG	Balanced analgesia using ketorolac and morphine	Sequential intravenous administration of ketorolac and morphine
DRUG	Pain control with single analgesics (ketorolac)	This arm do not use balanced analgesia. Instead, ketorolac IV administration followed by 50cc normal saline administration (for blinding) will be used in this group.

Timeline

• Start date: 2012-12-01
• Primary completion: 2013-12-01
• Completion: 2013-12-01
• First posted: 2012-03-02
• Last updated: 2012-12-17

Locations

1 site across 1 country: South Korea