NCT01540877

A Human Experimental Model for Neuropathic Pain Using Combined Application of Capsaicin and Local Anesthetics

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Ruhr University of Bochum · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Main of the present study was to develop a model of concomitant C-fibre block and sensitization eliciting spontaneous pain as well applying topical capsaicin and local anesthetics (LA) to examine the sensory alterations after combined C-fiber block and sensitization in both different application orders (sensitization of blocked C-fibers and block of sensitized C-fibers), compared to each of both mechanisms alone. Thereby, we expect stronger sensory changes during the combined substance application than during the monoapplication. We expect also contralateral sensory alterations mirroring the changes on the intervention site after the combined capsaicin and LA application, being stronger than after sensitization alone absent after C-fiber block alone.

Conditions

• Ipsi- and Contralateral Hypoesthesia

Interventions

Type	Name	Description
PROCEDURE	Application of capsaicin 0.6%	topical application of 0.6% capsaicin on the volar forearm
PROCEDURE	Application of local anesthetics (EMLA plaster)	topical application of EMLA on the volar forearm
PROCEDURE	Application of 1 capsaicin 0.6% and 2. EMLA	topical application of 1. 0.6% capsaicin and 2. EMLA on the volar forearm
PROCEDURE	Application of 1. EMLA and 2. capsaicin 0.6%	topical application of 1. EMLA and 2. 0.6% capsaicin on the volar forearm

Timeline

• Start date: 2011-04-01
• Primary completion: 2011-09-01
• First posted: 2012-02-29
• Last updated: 2012-02-29

Locations

1 site across 1 country: Germany