Trials / Completed
CompletedNCT01540578
Studying Biomarkers as a Diagnostic Tool in Samples From Younger Patients With B-Cell Acute Lymphoblastic Leukemia
OBSERVATIONAL: Replication Profiling as a Diagnostic Tool in B-cell Acute Lymphoblastic Leukemia (ALL)
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 70 (actual)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
This clinical trial is studying biomarkers as a diagnostic tool in samples from younger patients with B-cell acute lymphoblastic leukemia. Finding specific biomarkers may help improve the treatment of patients with B-cell acute lymphoblastic leukemia
Detailed description
STUDY SUBTYPE: Ancillary/Correlative OBSERVATIONAL STUDY MODEL: Case-only TIME PERSPECTIVE: Retrospective BIOSPECIMEN RETENTION: Samples with DNA BIOSPECIMEN DESCRIPTION: Fresh and frozen bone marrow cells STUDY POPULATION DESCRIPTION: Patients with B-cell acute lymphoblastic samples banked at the COG Cell Bank SAMPLING METHOD: Non-probability sample OBJECTIVES: I. To determine whether we can identify individuals within a specific sub-group of pre-B acute lymphoblastic leukemia (ALL) patients that will eventually recur. II. To identify replication-timing changes as a biomarker for further risk prediction. III. To identify differences between patients of similar subtype, and choose candidate differences to analyze by methods that are compatible with frozen samples. OUTLINE: Archived cell samples are analyzed for replication timing by flow cytometry, microarray, and single-cell fluorescence in situ hybridization (FISH) assays. Replication-timing results among cases and controls are also analyzed.
Conditions
- B-cell Childhood Acute Lymphoblastic Leukemia
- Childhood Acute Lymphoblastic Leukemia in Remission
- Recurrent Childhood Acute Lymphoblastic Leukemia
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | laboratory biomarker analysis | Correlative studies |
Timeline
- Start date
- 2012-02-01
- Primary completion
- 2016-05-01
- First posted
- 2012-02-29
- Last updated
- 2016-05-18
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT01540578. Inclusion in this directory is not an endorsement.