NCT01539772

Becker Muscular Dystrophy - A Natural History Study to Predict Efficacy of Exon Skipping

PITT0112: Becker Muscular Dystrophy - A Natural History Study to Predict Efficacy of Exon Skipping

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 85 (actual)
• Sponsor: Cooperative International Neuromuscular Research Group · Network
• Sex: Male
• Age: 4 Years
• Healthy volunteers: Not accepted

Summary

This is a multi-center natural history study that will be conducted at participating centers in the Cooperative International Neuromuscular Research Group (CINRG). Following a baseline evaluation, participants will have three follow-up visits over a three-year period. The investigators will characterize the Becker muscular dystrophy phenotype, and correlate specific abnormal dystrophin proteins with the range of clinical outcomes.

Detailed description

We will utilize the Cooperative International Neuromuscular Research group (CINRG) network to collect cohorts of Becker muscular dystrophy (BMD) patients with in-frame deletions in the dystrophin gene. We will collect clinical data across multiple body systems and correlate these findings to the high-resolution deletion break-point mapping performed from the tissue samples. We will investigate the observed variability to deepen our understanding of molecular mechanisms relevant to the optimization of exon skipping therapeutic approaches.

Conditions

• Becker Muscular Dystrophy

Timeline

• Start date: 2012-04-01
• Primary completion: 2018-08-01
• Completion: 2018-08-01
• First posted: 2012-02-28
• Last updated: 2018-06-15

Locations

16 sites across 4 countries: United States, Canada, Italy, United Kingdom