NCT01536964

The Effect of Morphine on Prasugrel Absorption in STEMI Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Heart Attacks are a major cause of death in this country. When patients have a heart attack, they are treated with anti-clotting drugs, one of which is a drug called Prasugrel. It is important that Prasugrel starts to work as quickly as possible following a heart attack. As many patients who have a heart attack experience excruciating pain, they are often given morphine (a strong painkiller) by the Ambulance crew. We think that morphine may affect how Prasugrel is absorbed from the stomach and may delay how quickly it starts to work. We intend to study the effect of morphine on the absorption of Prasugrel.

Conditions

• Cardiovascular Disease

Interventions

Type	Name	Description
DRUG	morphine	2.5mg of morphine will be given post Prasugrel administration with a further 2.5mg 5 minutes later
DRUG	saline	2.5ml of saline will be given post Prasugrel followed by a further 2.5ml as a comparator for the morphine

Timeline

• Start date: 2012-04-01
• Primary completion: 2013-03-01
• Completion: 2013-03-01
• First posted: 2012-02-22
• Last updated: 2022-06-14

Locations

1 site across 1 country: United Kingdom