NCT01536301

Oxycodone Versus Intravenous Morphine for Postoperative Analgesia After Hip Surgery

Evaluation of Oxycodone Hydrochloride Versus Intravenous Morphine Hydrochloride for Postoperative Analgesia After Hip Prosthetic Surgery

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 246 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The main objective is to demonstrate that postoperative analgesia by IV oxycodone (compared to morphine IV) reduces opioid-related adverse events (nausea, vomiting, pruritus, respiratory depression, urinary retention, allergies, hallucination) by 50% in adult patients operated on for prosthetic hip surgery.

Conditions

• Arthroplasty, Replacement, Hip

Interventions

Type	Name	Description
DRUG	Standard Care morphine hydrochloride	Post-operative analgesia including morphine (patient controlled analgesia).
DRUG	Oxycodone	Post-operative analgesia including oxycodone (patient controlled analgesia).

Timeline

• Start date: 2012-06-01
• Primary completion: 2016-11-15
• Completion: 2016-11-15
• First posted: 2012-02-22
• Last updated: 2025-11-19

Locations

2 sites across 1 country: France