NCT01534390

Influence of In-line Microfilters on Systemic Inflammation in Adult Critically Ill Patients

The Influence of In-line Microfilters on Systemic Inflammation in Adult Critically Ill Patients: A Prospective, Randomized, Controlled Trial

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 504 (actual)
• Sponsor: University of Salzburg · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Studies showed that infusion or injection of drugs and fluids results in introduction of microparticles into the bloodstream. These microparticles may cause organ damage and stimulate the immune system thus aggravating the underlying disease. Given that critically ill patients are characteristically suffering from a high disease severity and receive large amounts of fluids and drugs, they may be at particular risk of harm by these microparticles. In-line microfilters have been shown to clear microparticles from intravenous drugs and solutions. The investigators hypothesize that use of in-line microfilters reduce the days with the systemic inflammatory response syndrome in adult critically ill patients.

Conditions

• Systemic Inflammation

Interventions

Type	Name	Description
DEVICE	In-line microfilter (Supor IV Filter; Pall Corporation, Port Washington, New York)	use of in-line microfilters with a pore size of 0,2 mcm and 1,2 mcm (only if parenteral nutrition is administered) at all intravenous accesses

Timeline

• Start date: 2012-04-01
• Primary completion: 2013-04-01
• Completion: 2015-05-01
• First posted: 2012-02-16
• Last updated: 2015-06-02

Locations

1 site across 1 country: Austria