NCT01534078

Brentuximab Vedotin Plus AVD in Limited-stage Hodgkin Lymphoma

Brentuximab Vedotin Plus AVD in Non-bulky Limited Stage Hodgkin Lymphoma

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Brentuximab is an antibody-drug conjugate (ADC), which is the combination of an antibody (a protein that binds to cells) and a chemotherapy molecule. Brentuximab works by using the antibody portion to enter into the Hodgkin lymphoma cells and then releasing the chemotherapy portion, which attempts to destroy the cell. The intravenous chemotherapy drugs Adriamycin, Vinblastine and Dacarbazine (AVD) which you will receive in this research study are approved for use in people with Hodgkin Lymphoma. A drug called bleomycin is usually included with AVD, but since it appears to be a less effective drug with significant potential risks, it is being replaced in this study with the drug brentuximab. In this research study, the investigators are looking to see whether brentuximab in combination with AVD is effective in treating limited-stage Hodgkin Lymphoma.

Detailed description

Each treatment cycle is 28 days. You will receive brentuximab alone on Day 1 and 15 of the first cycle (lead-in cycle). After cycle 1, you will receive brentuximab combined with AVD on Day 1 and 15 for 4-6 cycles, depending on your response to therapy. Brentuximab and AVD will be given to you by intravenous infusion (IV). The following test and procedures will be performed on Days 1 and 15 of each cycle: * Review of any side effects you have experienced and all medications you are taking * Performance Status * Physical exam and vital signs * Routine blood tests * Questionnaire to evaluate symptoms of neuropathy * Research blood sample to look at markers to see how your body is responding to study medication * PET-CT scan prior to completing cycle 2 of combination brentuximab/AVD After the final dose of the study drug: The following assessments will be performed within one month of your last dose of study medication: * Review of any side effects you have experienced and all medications you are taking * Performance Status * Physical exam and vital signs * Routine blood tests * Questionnaire to evaluate symptoms of neuropathy * Research blood sample to look at markers to see how your body is responding to study medication * PET-CT scan Follow up will include the following * Review of any side effects you have experienced and all medications you are taking * Performance Status * Review and Physical exam * Routine blood tests * Questionnaire to evaluate symptoms of neuropathy * CT scans

Conditions

• Hodgkin Lymphoma

Interventions

Type	Name	Description
DRUG	Brentuximab Vedotin	2 doses administered 14 days apart; followed by combination therapy with AVD for 4-6 cycles; 1.2 mg/kg
DRUG	Adriamycin, vinblastine, and dacarbazine	Combination therapy with brentuximab for 4-6 cycles; 25 mg/m2 Adriamycin; 6 mg/m2 Vinblastine; 375 mg/m2 Dacarbazine

Timeline

• Start date: 2012-03-01
• Primary completion: 2015-01-01
• Completion: 2018-01-01
• First posted: 2012-02-16
• Last updated: 2018-02-20
• Results posted: 2017-08-30

Locations

4 sites across 1 country: United States