NCT01533597

The Efficacy of Solifenacin With or Without Tamsulosin in Adult Women With Overactive Bladder (OAB)

Comparison of the Efficacy of Solifenacin With or Without Tamsulosin in Adult Women With OAB: A Prospective Randomized Multicenter Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Soonchunhyang University Hospital · Academic / Other
• Sex: Female
• Age: 20 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to investigate if the combination therapy consisting of anticholinergics plus alpha-blockers could be beneficial for women suffering from Overactive Bladder (OAB).

Detailed description

Overactive bladder (OAB) describes the symptom complex of urgency, with or without urge incontinence, usually with frequency and nocturia. The lower urinary tract is innervated by both the parasympathetic and the sympathetic nervous system, that act via muscarinic and adrenergic receptors, respectively. Antimuscarinics are mainly used for the treatment of patients with OAB, especially women. Other than antimuscarinics, a1-blockers have been shown in several clinical reports to be useful in treating DO caused by neurological diseases.

Conditions

• Overactive Bladder

Interventions

Type	Name	Description
DRUG	Solifenacin	Solifenacin (5mg, qd, oral)
DRUG	Solifenacin plus Tamsulosin	Solifenacin (5mg, qd, oral) plus Tamsulosin (0.2mg, qd, oral)

Timeline

• Start date: 2010-12-01
• Primary completion: 2013-12-01
• Completion: 2014-02-01
• First posted: 2012-02-15
• Last updated: 2015-01-27
• Results posted: 2015-01-27

Locations

1 site across 1 country: South Korea