NCT01532193

The Effect of Embryo Culture Under Low Oxygen Tension on Pregnancy Rates

A Randomized Controlled Trial Evaluation the Effect of Low Oxygen Tension on the Pregnancy Rate After Day 3 Embryo Transfer in an Egg Donation Programme.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 380 (actual)
• Sponsor: Instituto Valenciano de Infertilidad, IVI VALENCIA · Academic / Other
• Sex: Female
• Age: 25 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This study will determine whether the use of low oxygen tension during "in vitro" embryo culture may increase the pregnancy rates in women undergoing egg donation.

Detailed description

As far as oxygen (O2) tension is concerned, both oocytes and embryos from different mammalian species included the human are normally surrounded by values which are much less than half of atmospheric O2, ranging from high (8.7% O2) in the rabbit oviduct, rabbit and hamster uterus, to as low as 11 mm Hg (1.5% O2) in the monkey uterus. Even in the preovulatory follicle, oocytes are bathed within follicular fluids containing oxygen that range from \> 1 to 5.5 % The aim of this study was to evaluate the impact the effect of low oxygen tension after day-3 embryo transfer in our egg donation programme on pregnancy and implantation rates.

Conditions

• Low Oxygen Tension

Interventions

Type	Name	Description
OTHER	Decreased oxygen concentration	The oxygen concentration is decreased during the "in Vitro" embryo culture.

Timeline

• Start date: 2009-11-01
• Primary completion: 2012-03-01
• Completion: 2012-03-01
• First posted: 2012-02-14
• Last updated: 2015-08-26

Locations

1 site across 1 country: Spain