NCT01531946

Acute MRI in Transient Ischemic Attack

Acute MRI-techniques for the Detection of Ischemic Lesions After Transient Ischemic Attack

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 199 (actual)
• Sponsor: Bispebjerg Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA). Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases. It is possible that the addition of Arterial spin labeling (ASL) perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate diagnosis.

Detailed description

The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA). Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases. It is possible that the addition of ASL-perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate and selective diagnosis of TIA. Patients admitted with clinical signs of TIA can be included. Patients will be examined with the TIA protocol in reference to the standardized clinical care: 1. 1,5 tesla gradient echo and 3 tesla Susceptibility weighted imaging (SWI) to detect microbleed as sign of small vessel disease. 2. Axial T2 FLAIR to detect white matter lesions. 3. Axial DWI to detect areas with impeded diffusion. (Total scantime 10min) If no signs of ischemic lesions is detected the following additional research scan-protocol will be initiated: 1. Perfusion without contrast: Arterial spin labeling (ASL) with the ability of showing signs of ischemia. 2. Diffusion tensor imaging (DTI): Has a higher sensitivity than DWI in displaying local ischemic lesions. (Total additional scantime 10min) All in All 20min in the scanner.

Conditions

• Ischemic Attack, Transient

Interventions

Type	Name	Description
PROCEDURE	MRI Scan	Patients will have to spend additional 10min in the scanner. Additional scan modalities used: 1. Perfusion without contrast: Arterial spin labeling (ASL) with the ability of showing signs of ischemia. 2. Diffusion tensor imaging (DTI): Has a higher sensitivity than DWI in displaying local ischemic lesions. An overall 20min scan period.

Timeline

• Start date: 2012-01-01
• Primary completion: 2017-05-01
• Completion: 2017-05-01
• First posted: 2012-02-13
• Last updated: 2021-01-28

Locations

1 site across 1 country: Denmark